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Charles River Laboratories

278.26

+5.261.93%

Post-market: 278.260.00000.00%19:30 EDT

Volume:767.56K

Turnover:213.40M

Market Cap:13.28B

PE:-57.00

High:280.40

Open:276.01

Low:275.63

Close:273.00

52wk High:303.31

52wk Low:144.26

Shares:47.74M

Float Shares:47.20M

Volume Ratio:1.05

T/O Rate:1.63%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-4.8814

EPS(LYR):-2.9122

ROE:-7.52%

ROA:4.11%

PB:4.68

PE(LYR):-95.55

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Overview Company News Filings

Charles River Q1 FY26 turns to net loss of $14.8 million; revenue rises 1.2% to $995.8 million

Charles River Q1 Adj. EPS $2.06 Beats $1.94 Estimate, Sales $995.830M Beat $977.486M Estimate

Benzinga Earnings

Charles River Laboratories International Inc - Reaffirms 2026 Guidance for Organic Revenue and Non-Gaap Earnings per Share

THOMSON REUTERS

Charles River Outlook FY Revenue Growth -5.5 to -4%

THOMSON REUTERS

Charles River Laboratories International - Expects to Complete Sale of Certain European Discovery Services Sites in May 2026

THOMSON REUTERS

Press Release: Pharming Group reports first quarter 2026 financial results; on track for Joenja(R) U.S. pediatric label expansion and launches in Japan and Europe in 2026

Charles River Laboratories International Inc. Stock Underperforms Wednesday When Compared To Competitors

Charles River Laboratories International Inc. Stock Outperforms Competitors On Strong Trading Day

Earning Preview: Charles River Laboratories this quarter’s revenue is expected to increase by 3.77%, and institutional views are broadly bullish

Charles River Laboratories International Inc. Stock Underperforms Wednesday When Compared To Competitors

Charles River Laboratories International Inc. Stock Underperforms Tuesday When Compared To Competitors

Charles River Laboratories International Inc. Stock Outperforms Competitors On Strong Trading Day

Charles River Laboratories International Inc. Stock Slides 9.2%, Underperforms Peers

AbbVie receives CRL from FDA regarding BLA for trenibotulinumtoxinE

Grace Therapeutics Provides Regulatory Update on New Drug Application for GTx-104

Revvity Falls 15.5%, Bio-Techne Drops 10.1%, IQVIA Drops 8.3%, Charles River Down 7%

THOMSON REUTERS

Shares of Biotech and Medical Equipment Cos Fall After Thermo Fisher Results, Outlook

THOMSON REUTERS

Charles River Laboratories International Inc. Stock Underperforms Tuesday When Compared To Competitors

Charles River reports results of restrospective analysis on VCGs in toxicology

Charles River analysis finds virtual control groups match NOAEL outcomes in toxicology studies

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While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpre","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260507:nNDL3G9Jnw:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU0029874061.USD","BK4585","BK4588","BK4530","LU0128526141.USD","LU0390134368.USD","LU0757428866.USD","BK4121","LU1815336091.USD","CRL","IE00BFMHRM44.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633143207","title":"Charles River Q1 Adj. EPS $2.06 Beats $1.94 Estimate, Sales $995.830M Beat $977.486M Estimate","url":"https://stock-news.laohu8.com/highlight/detail?id=2633143207","media":"Benzinga Earnings","labels":["express"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633143207?lang=en_us&edition=fundamental","pubTime":"2026-05-07 19:01","pubTimestamp":1778151660,"startTime":"0","endTime":"0","summary":"Charles River Q1 Adj. EPS $2.06 Beats $1.94 Estimate, Sales $995.830M Beat $977.486M Estimate","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.benzinga.com/quote/CRL","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"express","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4530","BK4121","LU0757428866.USD","LU0029874061.USD","LU1815336091.USD","IE00BFMHRM44.USD","BK4585","LU0390134368.USD","CRL","BK4588","LU0128526141.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633434141","title":"Charles River Laboratories International Inc - Reaffirms 2026 Guidance for Organic Revenue and Non-Gaap Earnings per Share","url":"https://stock-news.laohu8.com/highlight/detail?id=2633434141","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633434141?lang=en_us&edition=fundamental","pubTime":"2026-05-07 19:00","pubTimestamp":1778151602,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260507:nPLXE3D49A:5","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IE00BFMHRM44.USD","LU0029874061.USD","LU1815336091.USD","BK4530","BK4585","LU0128526141.USD","LU0757428866.USD","CRL","BK4588","LU0390134368.USD","BK4121"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633145513","title":"Charles River Outlook FY Revenue Growth -5.5 to -4%","url":"https://stock-news.laohu8.com/highlight/detail?id=2633145513","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633145513?lang=en_us&edition=fundamental","pubTime":"2026-05-07 19:00","pubTimestamp":1778151602,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260507:nPLXE3D49A:7","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4530","BK4121","LU0757428866.USD","LU0029874061.USD","LU1815336091.USD","IE00BFMHRM44.USD","BK4585","LU0390134368.USD","CRL","BK4588","LU0128526141.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633143169","title":"Charles River Laboratories International - Expects to Complete Sale of Certain European Discovery Services Sites in May 2026","url":"https://stock-news.laohu8.com/highlight/detail?id=2633143169","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633143169?lang=en_us&edition=fundamental","pubTime":"2026-05-07 19:00","pubTimestamp":1778151602,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260507:nPLXE3D49A:6","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["LU0757428866.USD","LU0029874061.USD","CRL","BK4585","BK4121","LU1815336091.USD","BK4588","BK4530","LU0128526141.USD","IE00BFMHRM44.USD","LU0390134368.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633904196","title":"Press Release: Pharming Group reports first quarter 2026 financial results; on track for Joenja(R) U.S. pediatric label expansion and launches in Japan and Europe in 2026","url":"https://stock-news.laohu8.com/highlight/detail?id=2633904196","media":"Dow Jones","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633904196?lang=en_us&edition=fundamental","pubTime":"2026-05-07 13:00","pubTimestamp":1778130000,"startTime":"0","endTime":"0","summary":"-- First quarter 2026 total revenues were US$72.4 million, an 8% decrease. -- RUCONEST revenue was US$58.4 million, a 15% decrease compared to the. first quarter 2025, mainly due to anticipated inventory drawdowns and the. -- Joenja revenue was US$14.1 million, a 34% increase compared to the. first quarter of 2025, reflecting strong U.S. and international momentum. -- Joenja approved in Japan and received positive CHMP opinion for APDS. -- Resubmitted pediatric sNDA to the FDA for Joenja  for. First--quarter RUCONEST revenue was impacted by several factors we had largely anticipated and incorporated into our full-year guidance, notably specialty pharmacy inventory drawdowns and our strategic exit from non-U.S. markets. We continue to see the overwhelming majority of patients stay on RUCONEST nine months after the launch of a new oral treatment. New patient enrollments and growing prescriber engagement further validate RUCONEST's strong value proposition for high-burden patients.","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["EC","BK4139","BK4201","BK4232","BK4121","IE00BFMHRM44.USD","LU0757428866.USD","LU1815336091.USD","PHAR","EEA","CRL","LU0128526141.USD","BK4022","BK4588","LU0029874061.USD","BK4585","LU0390134368.USD","R","BK4530"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633330168","title":"Charles River Laboratories International Inc. Stock Underperforms Wednesday When Compared To Competitors","url":"https://stock-news.laohu8.com/highlight/detail?id=2633330168","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633330168?lang=en_us&edition=fundamental","pubTime":"2026-05-07 05:16","pubTimestamp":1778102160,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Charles River Laboratories International Inc.  slipped 1.97% to $181.73 Wednesday, on what proved to be an all-around positive trading session for the stock market, with the S&P 500 Index  rising 1.46% to 7,365.12 and the Dow Jones Industrial Average  rising 1.24% to 49,910.59.The stock's fall snapped a two-day winning streak.Charles River Laboratories International Inc. closed 20.60% below its 52-week high of $228.88, which the company reached on January 13th.The stock demonstrated a mixed performance when compared to some of its competitors Wednesday, as Labcorp Holdings Inc.  fell 0.08% to $256.94, Alnylam Pharmaceuticals Inc.  rose 0.63% to $303.00, and Bio-Techne Corp.  fell 16.36% to $47.41.Data source: Dow Jones Market Data, FactSet. Data compiled May 6, 2026.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CRL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2633161961","title":"Charles River Laboratories International Inc. Stock Outperforms Competitors On Strong Trading Day","url":"https://stock-news.laohu8.com/highlight/detail?id=2633161961","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2633161961?lang=en_us&edition=fundamental","pubTime":"2026-05-05 05:18","pubTimestamp":1777929480,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Charles River Laboratories International Inc.  rallied 3.94% to $172.32 Monday, on what proved to be an all-around rough trading session for the stock market, with the S&P 500 Index  falling 0.41% to 7,200.75 and Dow Jones Industrial Average  falling 1.13% to 48,941.90.Charles River Laboratories International Inc. closed 24.71% below its 52-week high of $228.88, which the company reached on January 13th.The stock outperformed some of its competitors Monday, as Labcorp Holdings Inc.  fell 1.11% to $253.01, Alnylam Pharmaceuticals Inc.  rose 0.61% to $297.93, and Bio-Techne Corp.  fell 0.51% to $54.74.Trading volume  remained 152,148 below its 50-day average volume of 896,338.Data source: Dow Jones Market Data, FactSet. Data compiled May 4, 2026.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswir","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CRL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1126783324","title":"Earning Preview: Charles River Laboratories this quarter’s revenue is expected to increase by 3.77%, and institutional views are broadly bullish","url":"https://stock-news.laohu8.com/highlight/detail?id=1126783324","media":"Earnings Agent","labels":["earningPreview"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1126783324?lang=en_us&edition=fundamental","pubTime":"2026-04-30 23:05","pubTimestamp":1777561528,"startTime":"0","endTime":"0","summary":"Abstract Charles River Laboratories is scheduled to report fiscal first‑quarter 2026 results on May 7, 2026 Pre-Market; consensus anticipates modest year-over-year revenue growth with softer earnings...","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":"Earning Preview: Charles River Laboratories this quarter’s revenue is expected to increase by 3.77%, and institutional views are broadly bullish","news_tag":"earningPreview","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CRL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2631524763","title":"Charles River Laboratories International Inc. Stock Underperforms Wednesday When Compared To Competitors","url":"https://stock-news.laohu8.com/highlight/detail?id=2631524763","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2631524763?lang=en_us&edition=fundamental","pubTime":"2026-04-30 05:19","pubTimestamp":1777497540,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Charles River Laboratories International Inc.  slipped 1.77% to $163.84 Wednesday, on what proved to be an all-around grim trading session for the stock market, with the S&P 500 Index  falling 0.04% to 7,135.95 and Dow Jones Industrial Average  falling 0.57% to 48,861.81.This was the stock's second consecutive day of losses.Charles River Laboratories International Inc. closed 28.42% short of its 52-week high of $228.88, which the company achieved on January 13th.The stock demonstrated a mixed performance when compared to some of its competitors Wednesday, as Labcorp Holdings Inc.  fell 0.94% to $257.14, Alnylam Pharmaceuticals Inc.  fell 0.30% to $301.19, and Bio-Techne Corp.  fell 2.92% to $51.95.Data source: Dow Jones Market Data, FactSet. Data compiled April 29, 2026.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independe","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CRL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2631982531","title":"Charles River Laboratories International Inc. Stock Underperforms Tuesday When Compared To Competitors","url":"https://stock-news.laohu8.com/highlight/detail?id=2631982531","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2631982531?lang=en_us&edition=fundamental","pubTime":"2026-04-29 05:18","pubTimestamp":1777411080,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Charles River Laboratories International Inc.  slipped 2.59% to $166.79 Tuesday, on what proved to be an all-around poor trading session for the stock market, with the S&P 500 Index  falling 0.49% to 7,138.80 and Dow Jones Industrial Average  falling 0.05% to 49,141.93.The stock's fall snapped a two-day winning streak.Charles River Laboratories International Inc. closed 27.13% below its 52-week high of $228.88, which the company reached on January 13th.The stock demonstrated a mixed performance when compared to some of its competitors Tuesday, as Labcorp Holdings Inc.  fell 1.47% to $259.57, Alnylam Pharmaceuticals Inc.  fell 2.07% to $302.11, and Bio-Techne Corp.  fell 2.90% to $53.51.Data source: Dow Jones Market Data, FactSet. Data compiled April 28, 2026.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Do","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CRL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2630820234","title":"Charles River Laboratories International Inc. Stock Outperforms Competitors On Strong Trading Day","url":"https://stock-news.laohu8.com/highlight/detail?id=2630820234","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2630820234?lang=en_us&edition=fundamental","pubTime":"2026-04-25 05:18","pubTimestamp":1777065480,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Charles River Laboratories International Inc.  rallied 1.23% to $169.80 Friday, on what proved to be an all-around mixed trading session for the stock market, with the S&P 500 Index  rising 0.80% to 7,165.08 and the Dow Jones Industrial Average  falling 0.16% to 49,230.71.Charles River Laboratories International Inc. closed 25.81% short of its 52-week high of $228.88, which the company reached on January 13th.The stock demonstrated a mixed performance when compared to some of its competitors Friday, as Labcorp Holdings Inc.  fell 0.42% to $263.80, Alnylam Pharmaceuticals Inc.  fell 2.63% to $305.54, and Bio-Techne Corp.  rose 3.80% to $54.19.Trading volume  remained 348,813 below its 50-day average volume of 1.1 M.Data source: Dow Jones Market Data, FactSet. Data compiled April 24, 2026.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is pu","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CRL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2629630118","title":"Charles River Laboratories International Inc. Stock Slides 9.2%, Underperforms Peers","url":"https://stock-news.laohu8.com/highlight/detail?id=2629630118","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629630118?lang=en_us&edition=fundamental","pubTime":"2026-04-24 04:34","pubTimestamp":1776976440,"startTime":"0","endTime":"0","summary":"This article was automatically generated by Dow Jones using technology from Automated Insights.Shares of Charles River Laboratories International Inc. slipped 9.2% to $167.74 on what proved to be an all-around dismal trading session for the stock market, with the S&P 500 Index falling 0.4% to 7,108.40 and Dow Jones Industrial Average falling 0.4% to 49,310.32.Charles River Laboratories International Inc. closed 26.7% short of its 52-week high of $228.88, which the company reached on January 13th.The stock demonstrated a mixed performance when compared to some of its peers, as Labcorp Holdings Inc. fell 2.8% to $264.92, Alnylam Pharmaceuticals Inc. rose 1.0% to $313.79, and Bio-Techne Corp. fell 10.89% to $52.20.Trading volume totaled 1.2 million, compared to the 50-day average of 1.1 million.","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CRL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2629853863","title":"AbbVie receives CRL from FDA regarding BLA for trenibotulinumtoxinE","url":"https://stock-news.laohu8.com/highlight/detail?id=2629853863","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629853863?lang=en_us&edition=fundamental","pubTime":"2026-04-24 04:13","pubTimestamp":1776975181,"startTime":"0","endTime":"0","summary":"AbbVie (ABBV) announced that it received a Complete Response Letter from the U.S. FDA regarding the Biologics License Application for trenibotulinu...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/abbvie-receives-crl-from-fda-regarding-bla-for-trenibotulinumtoxine-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/abbvie-receives-crl-from-fda-regarding-bla-for-trenibotulinumtoxine-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0757428866.USD","LU2129689514.USD","LU1244550494.USD","LABU","LU0661504455.SGD","LU1244550577.SGD","LU1989772840.SGD","IE00B19Z3B42.SGD","LU2112291526.USD","LU0882574055.USD","IE00BJT1NW94.SGD","IE0004445239.USD","LU0417517546.SGD","LU0310799852.SGD","IE00BLSP4452.SGD","SG9999003800.SGD","IE00BFTCPJ56.SGD","ABBV","LU1718418525.SGD","LU0289739343.SGD","LU1162221912.USD","BK4588","BK4530","LU1093756325.SGD","LU1093756168.USD","LU0912757837.SGD","LU0985320562.USD","LU2089284900.SGD","LU1023059063.AUD","LU0553294199.USD","LU0029874061.USD","CRL","LU0795875169.SGD","LU0432979614.USD","IE00B2B36J28.USD","LU0390134368.USD","LU1551013342.USD","LU1061106388.HKD","LU0203345920.USD","LU0456855351.SGD","SG9999011175.SGD","BK4534","LU0965509010.AUD","LU2237443382.USD","LU1267930573.SGD","IE00BLSP4239.USD","IE00BVYPNV92.GBP","IE0002270589.USD","LU2089984988.USD","LU0738911758.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2629292851","title":"Grace Therapeutics Provides Regulatory Update on New Drug Application for GTx-104","url":"https://stock-news.laohu8.com/highlight/detail?id=2629292851","media":"GlobeNewswire","labels":["policyRegulatory"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629292851?lang=en_us&edition=fundamental","pubTime":"2026-04-24 01:13","pubTimestamp":1776964380,"startTime":"0","endTime":"0","summary":"FDA Issued Complete Response Letter Citing Outstanding Items Related to Chemistry, Manufacturing, and Controls and Non-Clinical Information FDA Does not Request Additional Clinical Data Company 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River Laboratories International Inc. Stock Underperforms Tuesday When Compared To Competitors","url":"https://stock-news.laohu8.com/highlight/detail?id=2629063255","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629063255?lang=en_us&edition=fundamental","pubTime":"2026-04-22 05:16","pubTimestamp":1776806160,"startTime":"0","endTime":"0","summary":"This article was automatically generated by MarketWatch using technology from Automated Insights.Shares of Charles River Laboratories International Inc.  slid 1.32% to $183.10 Tuesday, on what proved to be an all-around dismal trading session for the stock market, with the S&P 500 Index  falling 0.63% to 7,064.01 and Dow Jones Industrial Average  falling 0.59% to 49,149.38.The stock's fall snapped a two-day winning streak.Charles River Laboratories International Inc. closed 20.00% below its 52-week high of $228.88, which the company reached on January 13th.The stock demonstrated a mixed performance when compared to some of its competitors Tuesday, as Labcorp Holdings Inc.  rose 1.57% to $273.42, Alnylam Pharmaceuticals Inc.  fell 0.81% to $308.43, and Bio-Techne Corp.  fell 1.50% to $59.67.Data source: Dow Jones Market Data, FactSet. Data compiled April 21, 2026.This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["CRL"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2629003200","title":"Charles River reports results of restrospective analysis on VCGs in toxicology","url":"https://stock-news.laohu8.com/highlight/detail?id=2629003200","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629003200?lang=en_us&edition=fundamental","pubTime":"2026-04-21 21:34","pubTimestamp":1776778476,"startTime":"0","endTime":"0","summary":"Charles River (CRL) Laboratories International has shared the results of a retrospective analysis in Regulatory Toxicology and Pharmacology, showin...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/charles-river-reports-results-of-restrospective-analysis-on-vcgs-in-toxicology-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/charles-river-reports-results-of-restrospective-analysis-on-vcgs-in-toxicology-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0029874061.USD","BK4585","BK4588","BK4530","LU0128526141.USD","LU0390134368.USD","LU0757428866.USD","BK4121","LU1815336091.USD","CRL","IE00BFMHRM44.USD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2629903673","title":"Charles River analysis finds virtual control groups match NOAEL outcomes in toxicology studies","url":"https://stock-news.laohu8.com/highlight/detail?id=2629903673","media":"Reuters","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2629903673?lang=en_us&edition=fundamental","pubTime":"2026-04-21 20:05","pubTimestamp":1776773148,"startTime":"0","endTime":"0","summary":"Charles River published retrospective analysis showing virtual control groups can replace concurrent control groups in 20 toxicology studies without changing core study conclusions.Review reported 100% concordance in No Observed Adverse Effect Level across all studies.Endpoint-level differences emerged between virtual controls and concurrent controls, prompting ongoing model refinement with clients.Program targets up to 25% reduction in control-group animal use where scientifically appropriate.European Medicines Agency issued draft qualification focused on virtual control groups in non-GLP rat dose-range finding repeated-dose toxicity studies.Disclaimer: This news brief was created by Public Technologies  using generative artificial intelligence. While PUBT strives to provide accurate and timely information, this AI-generated content is for informational purposes only and should not be interpreted as financial, investment, or legal advice. Charles River Laboratories International Inc. 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